第九章抗生民素的生产.pptVIP

Ampicillin（氨卡青霉素） Discovered in 1963 One of only few penicillins that can be administered orally Has improved acid stability Broad spectrum. Amoxycillin（羟氨卡青霉素） The preffered choice of drug for oral use. The highest absorbance levels in the body First marketed in 1998 by Smitkline Beechams? Benefits of semi-synthetic variants Can be administered orally as they are resistant to stomach acid They have a broader spectrum of activity The semi-synthetic variant of penicillin is chemically more stable than the volatility of the B-Lactam ring, in the penicillin G 6-APA（6-氨基青霉烷酸） ? First d