细胞信号通路ppt细胞信号通路大全上下细胞信号通路ppt traf_pathway.pptVIP

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2021-04-04 发布于北京
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细胞信号通路ppt细胞信号通路大全上下细胞信号通路ppt traf_pathway.ppt

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TNFR2 TNFa/b TNFR1 TNFa TACI BAFF BCMA APRIL LMP1 NGFR NGF TLRs RANK RANKL TRAF Pathway TRAF6 TRAF6 TRAF6 TRAF6 TRAF6 TRAF2 TRAF2 cTRAF2 TRAF2 TRAF2 TRAF2 TRAF5 TRAF5 TRAF6 TRAF2 TRADD TRAF3 MADD FADD TOLLIP MyD88 TIRAP Ub PI3K Caspase8 Caspase3,6,7 IRAK TAB1 TAB2 TAK1 Src GCK/GCKR NIK ASK1 ASK1 I-TRAF RIP JNK p38 NF-kB IkBsDegradation P IkBs IKKs MEKK1 MKK7 SEK1 MEK3 MEK6 c-Jun c-Jun NF-kB c-Fos Direct Antimicrobial Response,Cell-Mediated Immunity and Apoptosis of Host Cell Cell Survival Gene Expression Pro-Inflammatory Cytokines(IL-12,IL-1 TNFa) Apoptosis CD40L CD40 IL-1a,b IL-1R TOLLIP MyD88 IRAK1,2 TRAF6 TRAF1,2,3,5 Akt/PKBPathway RIP TRAF6 TRAF2 CIAPs TRAF4 ROS 2009 ProteinL C * Review: The structural and metabolic integrity of bone is maintained through the dynamic process of bone remodeling that results from the coordinate action of bone resorption and the formation of new bone by osteoblasts. Regulation of bone remodeling occurs through multiple mechanisms that ultimately converge on the interaction of osteoclasts or their precursors with osteoblasts and bone marrow stromal cells. Two key factors supplied by the stromal environment are CSF1 (Colony-Stimulating Factor-1) and the TNF family member, RANKL (Receptor Activator of Nuclear Factor-KappaB Ligand, also called TRANCE, ODF, OPGL). Signaling through RANK is essential for the differentiation and activation of osteoclasts, the cell principally responsible for bone resorption. RANK provokes biochemical signaling via the recruitment of intracellular adaptor TRAFs (TNF [Tumor Necrosis Factor] Receptor-Associated Factors) after ligand binding and receptor oligomerization (Ref.1). TRAFs represent a group of structurally similar adaptor proteins characterized by having RING finger domains, multiple Zn2+ fingers, and a conserved COOH-terminal TD (TRAF Domain) (Ref.2). TRAFs function as molecular bridges, linking the cytosolic portions of the receptors to downstream protein kinases, ubiquitin li