钙通道阻滞药.pptVIP

2021/4/26 * * 2021/4/26 Chapter 20  钙通道阻滞药 Calcium channel blockers 2021/4/26 Calcium channel blocker ——通过干扰Ca2+通道活性， 阻滞膜外Ca2+从细胞外经电压依赖性钙通道流入细胞内的药物 又称钙拮抗药 calcium antagonists 2021/4/26 Calcium is involved in the initiation of smooth muscle, neurotransmitter release, cardiac cell contraction and in the propagation of the cardiac impulse. The calcium channel blockers inhibit the passage of calcium through the voltage gated L-type channels of smooth and cardiac muscle membrane, reduce cytoplasmic free calcium concentration and cause the muscle to relax. 2021/4/26 Type of calcium