补肾化瘀方联合西药治疗脑小血管病的临床研究.docxVIP

补肾化瘀方联合西药治疗脑小血管病的临床研究 Clinical study of Bushen Huayu Prescription combined with Western medicine in the treatment of cerebral small vessel disease LIANG Fang1 HUO Qingping1 CHEN Xu2 ZHAO Yuwu3 1.Department of Traditional Chinese Medicine， Shanghai Sixth People′s Hospital， Shanghai *****， China; 2.Department of Neurology， Shanghai Eighth People′s Hospital， Shanghai *****， China; 3.Department of Neurology， Shanghai Sixth People′s Hospital， Shanghai *****， China [Abstract] Objective To observe the curative effect of Bushen Huayu Prescription combined with Western medicine for intervenion of cerebral small vessel disease （CSVD）. Methods Total 252 subjects with CSVD were collected， the patients were from Shanghai Sixth People′s Hospital and Shanghai Eighth People′s Hospital， the time limit was from March 2015 to December 2017. All patients were divided into Bushen Huayu intervention group and placebo control group， with 126 cases in each group. The course was 24 weeks， the indices were detected at 0， 12， 24 weeks after intervention： 24 h ambulatory blood pressure; serum total cholesterol （TC）， triglyceride （TG）， high density lipoprotein cholesterol （HDL-C）， low density lipoprotein cholesterol （LDL-C）， fasting blood glucose （FBG）， 2-hour post-meal blood glucose （2hPBG）， glycosylated hemoglobin （HbA1c）， the changes of all indices above between two groups were compared before and after intervention， at the same time， and the changes of memory and executive screening scale （MES） of the two groups were compared at 0， 24 weeks after intervention. Results Before intervention， there were no statistically significant differences of the mean systolic blood pressure in 24 hours， mean diastolic blood pressure in 24 hours， TC， TG， LDL-C， HDL-C， FBG， 2hPBG and HbA1c between the two groups （P 0.05）; after intervention， the systolic blood pressure in 24 hours， mean diastolic blood pressure in 24 hours， TC， TG， LDL-C， FBG in the two groups were significantly lower than t