智慧人生之米氮平联合小剂量奥氮平治疗流浪抑郁症伴失眠患者对照研究.docVIP

米氮平结合小剂量奥氮平治疗漂泊抑郁症伴失眠患者的比较研究 【重点词】 漂泊抑郁症 ;失眠 ;米氮平 ;奥氮平中图分类号： r749.4+1 文件表记码： a doi ： a control study of mirtazapine combined with small dose of olanzapine in the treatment of the vagrant depression with insomnia li qibin ， tao linggang ， zhou yun ， yang yong ， xie zhengguo ，zhou linling abstract 】 objective to investigate the effect and safety of mirtazapine combined with small dose of olanzapine in the treatment of vagrant depression with insomnia. methods 96 cases of vagrant depression with insomnia treated in the rescue department of guilin mental health center from march ， 2014 to november ， ， effects and adverse reactions were assessed with hamilton rating scales of depression （hamd ）， hamilton anxiety scale （hama ）， pittsburgh sleep quality index （ psqi ） and treatment emergent symptom scale （tess ） before treatment and 1 ，2， 4，6 and 8 weeks after treatment ， respectively. conclusion mirtazapine combined with small dose of olanzapine in the treatment of vagrant depression with insomnia is better than single use of mirtazapine ， which can clearly improve the depressive symptoms and sleep quality of the patients with high safety ，and thus it is worthy of clinical recommendation. 【key words  】  vagrant depression;insomnia;mirtazapine;olanzapine 抑郁症是一种最常有的高生病率、高复发率、高自杀率的严重 精神疾病，绝大部分抑郁症患者伴有睡眠障碍 [1] 。当前抑郁症在第一次抗抑郁治疗过程中约有 1/3 的患者治疗效果欠佳 [2] 。有学者发现，在使用抗抑郁药治疗的基础上结合小剂量抗精神病药物可以达 到起效快、总体药物剂量小、不良反响轻微等增效作用 [3] 。我们观 察米氮平结合小剂量奥氮平治疗漂泊抑郁症伴失眠患者临床疗效及安全性，报告如下。 1 对象与方法 1.1 研究对象