药理学教学课件：Chapter 5 Overview of Efferent Nervous System.ppt

* * M1：The central cortex、hippocampus： Central excitatory effects. Presynaptic membrane ： Inhibiting the releasing of Ach. Ganglion： Depolarization of Ganglion Parietal cells of the gastric mucosa： Gastric acid secretion、Gastrointestinal motility. Eye： Narrowing of the pupil、Adjustment to myopia M2：CNS、 Presynaptic membrane : Inhibiting the release of Ach Heart (Sinoatrial node 、Atrium、Atrioventricular node、Ventricle): Inhibitory effects * * M3: Exocrine gland： Increased secretion of sweat gland、salivary gland Smooth muscles of stomach、intestina、 bronchial tube 、bladder: Excitation (contraction) Smooth muscles of Blood vessles: Expansion CNS： Inhibitory effects M4: Exocrine gland 、 Smooth muscles 、CNS M5: Central Nervous System * * Nicotine receptor ( NR ) N1 ( NN ) Recepor： N receptor on the ganglion N2 ( NM ) Recepor： N receptor on neuromuscular junction of skeletal muscle * * Model of Nicotinic Receptor It is belong to a ligand-gated ion channel recepter. Every N receptor consists of 2 α subunits and β、r、δ subunit. There is a transmembrane channel just in the middle of subunits. * * 1.2 Adrenoceptor ： The receptors is combined with NA and AD selectively. ? receptor ?1 receptor：Blood vessles at skin、mucosa、visceral organs —— Vasoconstriction Gastrointestinal smooth muscle —— Slack off * * Presynaptic membrane： Inhibting the release of N