药理学教学课件：Chapter 20 Antipyretic-analgesic and Anti-inflammatory Drugs.ppt

* Chapter 20 Antipyretic-analgesic and Anti-inflammatory Drugs ( Non-Steroidal Anti-Inflammatory Drugs, NSAIDs ) These drugs relieve the pain associated with inflammation, including that from arthritis and gout. They produce their anti-inflammatory action through a different mechanism, not as glucocorticoid. Classed into non-steroidal anti-inflammatory drugs (NSAIDs) in 1974. * * Introduction Non-Steroidal Anti-Inflammatory Drugs, NSAIDs A Antipyretic （一）PG Synthetase （Cyclooxygenase）in the hypothalamic thermoregulatory center Characteristics： Making cooling of body temprature of fever B Analgesic （一） PG Synthetase （Cyclooxygenase）in the peripheral pain position C Anti-Inflammatory （一） PG Synthetase （Cyclooxygenase）in the peripheral inflammatory position * Antipyretic Action Febrile: Endogenous pyrogen →CNS→Release PG↑ → Thermoregulatory center → Febrile Antipyretic: Inhibit PG synthetase，Decrease synthesis of PG →Hypothermy * depress bradykinin pain sensor antipyretic analgesic pain stimulus PG synthesis sensitization depress Mechanisms: Inhibit the synthesis of prostaglandins and prevent bradykinin from stimulating pain receptors, also inhibit the recognition of pain impulses peripherally. Analgesic Action * Anti-Inflammatory Action Mechanisms: Inhibit a primary pathway in PG synthesis. Summary: By inhibiting the PG synthesis to show antipyretic, analgesic and anti-inflammatory effects. * * NSAIDs show different effects to COX-1 and COX-2： The stronger the inhibiting effects to COX-1，the more adverse reaction the drug has； The stronger the inhibiting effects to COX-2， the more obvious the antipyretic-analgesic and anti-inflammatory effects the drug has. * Non Selectively Cyclooxygenase Inhibiting Drugs A Salicyl