现代乳癌内分泌治疗新方法.pptxVIP

乳癌内分泌治疗新思路和临床实践乳癌的治疗手段Surgery手术Radiation therapy 放疗Chemotherapy化疗Hormone therapy 内分泌治疗Biotherapy生物治疗New therapies新的治疗IIIIII乳癌内分泌治疗的发展1970198019902000ITamoxifenTamoxifen新的芳香化酶抑制剂IIMAAGTamoxifenpure A.E. ? 新的芳香化酶抑制剂IIIIIIMAExemestane /MAHormone Therapy Response Rate (%) in Different Receptor StatusSurvival by Response Arimidex 1 mg100CR or PR 24 wksStable Progression80% Survival 604020001234Years from Randomisation三苯氧胺 （TAM) 最重要的乳癌内分泌治疗药物 Prevention DCIS/ Neoadj AdjuvantMetastaticDisease 1st2nd3rdOVABL TAM TAMMAAGTAM5 yearsTAMTamoxifen for 5 Years vs No TreatmentRecurrencesBreast Deaths1001009