细胞信号转导障碍与疾病B.pptxVIP

肢瑞肥大症和巨人症 (Acromegaly and gigantism) 30 %?40 %垂体腺瘤;/;肿瘤;Table 7-6. SELECTED ONCOGENES, THEIR MODE OF ACTIVATION, AND ASSOCIATED HUMAN TUMORS;A. INCREASED GROWTH FACTOR PRODUCTION;bellar hemangioblastomas; renal cell carcinomas; angiomas and cysts of many visceral organs;Mutagenic agents;无活性的生长因*受体;弟三节 细胞信号转导调控与疾病防治;Managements ￡ Specific activator or inhibitor;以细胞信号转导分子为**点的抗肿捕药物 ? 蛋匂酪氨酸激酶CPTKJ抑制剂 SU5416, SU11248, CEP-701, PKC412 ? 法尼基转移酶CFTaseJ抑制剂 Ras成熟必须从丰胱氨酸残基成尼及化开始 伊马誉尼flmatinibj ,上市药名叫格利维克 (GleevecJ，一种治疗慢性髓.性匂血病的药物;Managements ￡ Specific activator or inhibitor;I I I I I W RNA ( dsRNA;In