心血管疾病治疗中作用于RAAS药物.pptVIP

心血管疾病治疗中作用于RAAS药物 Beta blocker Renin inhibitor ACE inhibitor Angiotensin II receptor antagonist Vaccines against angiotensin II ANP？？ 第二节 Beta blocker British scientist James W. Black successfully developed propranolol in the 1962 结构改造系列药物 β受体分布及效应 β1, β2 and β3 receptors. β1 in the heart and in the kidneys. β2 in the lungs, gastrointestinal tract, liver, uterus, vascular smooth muscle, and skeletal muscle. β3 in fat cells. 临床应用 心绞痛、房颤、心律失常、充血性心衰、特发性震颤、青光眼、高血压、偏头痛、二尖瓣脱垂、心肌梗塞、嗜铬细胞瘤、体位性心动过速、甲亢和焦虑的症状控制、茶碱过量、急性动脉剥离、肥厚梗阻性心肌病、马凡综合征、门脉高压静脉曲张出血预防、多汗症减轻症状 代表药物 Nonselective agents β1-selective a