教案t细胞亚群及记忆.pptxVIP

T细胞亚群及记忆细胞;More than 100 functionally distinct populations of lymphocytes can be identified in the peripheral blood of humans. It is no longer tenable to study immune-related effects using “bulk” lymphocytes populations such as “memory CD8+ T cells”. Investigation of the “fine” lymphocyte subsets is necessary to understand the mechanisms of immunological disease and protection.;;A new subset of Th cells—Th17;;Th17 and diseases;;一、Th辅助B细胞产生针对TDAg的抗体 ;;二、Tfh细胞表面标记、分化及发育;;三、Tfh细胞迁移、定位和功能 ;初始T;注:（1）由外周淋巴器官T细胞区高内皮微静脉（HEV）产生的SLC （secondary-lymphoid tissue chemokine）/CCL21招引表达CCR7的 初始T细胞从外周循环进入T细胞区； （2）T细胞与成熟树突状细胞（mDC）等APC相互作用后表达IL-6R和IL-21R， APC产生的IL-6与经抗原刺激后T细胞IL-6R结合； （3）活化T细胞表达高水平ICOS、IL-6R、IL-21R和CXCR5，IL-6和IL-21调节 Tfh细胞分化时通过其受体激活STAT3，表达有CXCR5的Tfh被滤泡基质 细胞（包括FDC、血管细胞和网状细胞）产生的BCA-1（B cell attracting chemokine）/CXCL13趋化迁移到淋巴小结，进一步形成生发中心； （4）高表达CXCR5 B细胞从T细胞区迁移到B细胞滤泡（未显示），Tfh-B细 胞相互作用，CD40L/CD40和ICOSL/ICOS共刺激分子以及Tfh分泌IL-21， 在Tfh辅助B细胞中发挥关键作用； （5）活化B细胞发生增殖分化、Ig类别转换和亲和力成熟。;四、T细胞和B细胞在何处、如何识别TD-Ag的T/B细胞表位 ;Fazilleau N, et al. Immunity 30, March 20, 2009;Immunity 30, March 20, 2009; 原来的Th1、Th2和其它T细胞亚群对B细胞仍有辅助作用，包括在滤泡内和其他淋巴组织，取决于趋化因子受体的种类和密度以及迁移能力。;TFH cells and autoimmunity;TFH cells and immunodeficiencies;;Introduction;TGF-β deviates TH2 cells to a “TH-9” fate;Function of IL-9+ T cells;TH9 cells lack suppressive function and promote tissue inflammation. ◆ TH9 cells also produced IL-10. However, unlike IL-10-producing Tr1 cells,TH9 cells do not have any suppressive effects in vitro but readily proliferate and thus act like effector T cells. ◆ Adoptive transfer of IL-9+ IL-10+ T cells into recombination- activating gene 1-deficient mice induced colitis and peripheral neuritis, the severity of which was aggravated if the IL-9+ IL- 10+ T cells were transferred with CD45RBhi CD4+ effector T cells