铜针留置治疗静脉畸形对体内溶血影响.docVIP

铜针留置治疗静脉畸形对体内溶血影响 ［摘要］目的：探讨铜针留置治疗静脉畸形是否会导致体内 溶血。方法：1999年1月?2006年1月采用铜针留置治疗 静脉畸形46例，男24例，女22例；年龄10?50岁，中位 年龄20岁。病变范围6cmX4cm?40cmX25cm。留置铜针10? 45枚/例，平均28枚，留置时间7天。术后密切观察患者全 身和局部变化以及有无急性溶血临床表现，检测其中8例患 者留置铜针前及留置1、4、7天后血清胆红素、外周血红细 胞及网织红细胞数、尿血红蛋白及含铁血黄素。结果：本组 46例留置铜针后9例出现腹痛、恶心、呕吐等症状，无急性 溶血临床表现，8例留置铜针1、4、7天后，血清总胆红素 及间接胆红素升高无显著性(P0. 05),尿血红蛋白及含铁 血黄素阴性，外周血红细胞比术前显著减少(P0. 05)但 仍在正常范围，网织红细胞在留置铜针7天后显著升高并超 出正常范围(P0. 05)o结论：铜针留置治疗血管瘤可引起 体内轻度溶血。 ［关键词］静脉畸形；铜针；溶血 ［中图分类号］R6223［文献标识码］A［文章编 号］1008-6455 (2008) 10-1488-03 Copper needle retained in malformed venouse effect on hemolysis in vivo FU Shi-zhang,YIN Guo-qian,WANG Bin,HUANG He-ping,HUANG Lin-ling (Department of Cosme tic and Plastic, Jiangxi Women and Children Health Care Hospital,Nanchang 330006,Jiangxi,China) Abstract : ObjectiveTo explore whether copper needles retained in malformed venouse will induce hemolysis in vivo. Methods46 cases with venouse malformation treated by 10 to 45 copper needles retained in malformed venouse for seven days from January 1999 to January 2006 were reviewed retrospectively, including 24 males and 22 females whose age ranged from 10?50 years and mean age was 20 years? These malformed venouses in size ranged from 6 cmX4 cm to 40 cmX25 cm. During the copper needle retainment,all the cases were observed for the whole and local symptom,as well as manifestation of acute hemolysis in vivo. The content of bilirubin in circular serum, amount of RBC and reticulocyte in circular blood, hemosiderin and hema to glob in in urine of 8 cases were detected before treatment and after copper needles retained for 1, 4, 7 days. ResuIts46 cases had no clinical manifestation of acute hemolysis in vivo after copper needles retainment, except that 9 cases of them had the sensations of abdominal pain,nausea , vomiting, and so on. After copper needles retained for 1,4,7 days, the content of total bilirubin and indirect bilirubin in circular serum increased with no statistical significance compared with that before treatment