出凝血功能的常用检测方法优秀课件.pptVIP

* Plaque rupture and exposure of the lipid core can at times result in extensive thrombus formation that is clinically manifested as an unstable coronary syndrome. Initially, tissue factor, collagen, vWF, and fibronectin attract and attach platelets to the vessel?wall, as well as activate them. vWF also binds platelets, causing a conformational change in the platelet itself. The platelet degranulates and secretes vasoconstrictive and chemoattractant substances. Exposure of the now-activated GP IIb/IIIa receptor site allows binding of fibrinogen to cause platelet aggregation by cross-linking of