学习病原生物学微生物gram negative bacilli.pptxVIP

Gram Negative Bacilli;Classification~29 genera over 100 species. ;;Enterobacteriaceae;Enterobacteriaceae;Enterobacteriaceae;Enterobacteriaceae;Enterobacteriaceae;Enterobacteriaceae;Escherichia coli; ;E. coli: Pathogenesis of urinary tract infection;UPEC; Gastroenteritis – there are several distinct types of E. coli that are involved in different types of astroenteritis: ;Enterotoxigenic E. coli ;Enterohemorrhagic E. coli (EHEC);;Sanitary significance;Shigella;Shigella;Antigen and classification;Shigella dysenteriae: Pathogenesis; ;Shigella attachment and penetration;Clinical Findings ;Interior mucosal surface of the rectum from a sigmoidoscopic view in a patient who presented with shigella dysentery. /phil/details.asp;无限生机;This man developed necrosis of the intestines due to a Shigellosis infection resulting in his death. ;Diagnostic Laboratory Test;Sanitary conditions (water, food, milk, sewage disposal);Shigella dysenteriae: Treatment;Salmonella;Salmonella;Criteria for distinguishingShigella vs. Salmonella;Appearance of Colonies on Salmonella-Shigella Agar ;;Antigens of major Salmonella serotypes ;Reservoir ;Reservoir;Salmonella: Pathogenesis;Complicated classification system because salmonellae are a group of closely related organisms rather than distinct species Clinically important serotypes: Salmonella typhi Salmonella paratyphi A Enteric Fever Salmonella schottmuelleri Salmonella choleraesuis Septicemia/Focal lesions Salmonella typhimurium Salmonella enteritidis;Enteric fever;“伤寒玛丽”，本名叫玛丽·梅伦(mary mallon)，1869年生于爱尔兰，15岁时移民美国。起初，她给人当女佣。后来，她发现自己很有烹调才能，于是转行当了厨师，每月能赚到比做女佣高出很多的薪水。玛丽对自己的处境非常满意。 　　1906年夏天，纽约的银行家华伦带着全家去长岛消夏，雇佣玛丽做厨师。8月底，华伦的一个女儿最先感染了伤寒。接着，华伦夫人、两个女佣、园丁和另一个女儿相继感染。他们消夏的房子住了11个人，就有6个人患病。 　　房主深为焦虑，他想方设法找到了有处理伤寒疫情经验的专家索柏(soper)。索柏将目标锁定在了玛丽身上。他详细调查了玛丽此前7年的工作经历，发现7年中玛丽更换过7个工作地点，而每个工作地点都曾暴发过伤寒病，累计共有22个病例，其中1例死亡。 　　于是，索柏想得到玛丽的血液、粪便样本，以验证自己的推断；但这非常棘手。索柏对此有过精彩的描述。他找到玛丽，“尽量使用外交语言，但玛丽很快就作出了反应。她抓起一把大杈子，朝我直戳过来。我飞快地跑过又长