MDR铜绿假单胞菌的流行病学和耐药机制.pptVIP

1.膜通透性 * * * the expression level of OprD2 among PA 19.33％ 46.47％ 34.2％ Note： significant decrease in the expression of OprD2 ( 0.4 ) * 2.外排泵机制 * 外排泵机制 * 外排泵机制 * Resistance mechanism－overexpression of efflux pumps  Adapted with permission from Livermore DM. Clin Infect Dis 2002;34:634-640. Efflux System Pump (Mex B)? Imipenem and meropenem enter here Meropenem is pumped out while imipenem is not Efflux System Exit Portal (OprM)? Outer Membrane Periplasm Linker Lipopro