人类白细胞抗原等位基因与HBV宫内感染关系.docVIP

人类白细胞抗原等位基因与HBV宫内感染关系 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：人类白细胞抗原等位基因与HBV宫内感染关系 1 1 对象与方法 3 12 方法 3 13 统计分析 4 2 结果 4 22 HLA-DR与HBV宫内感染的关系 5 3 讨论 6 文2：人类白细胞抗原等位基因与HBV宫内感染关系 7 1对象与方法 9 12方法 9 13统计分析 10 22hla-dr与hbv宫内感染的关系 11 参考文摘引言： 13 原创性声明（模板） 15 文章致谢（模板） 15 正文 人类白细胞抗原等位基因与HBV宫内感染关系 文1：人类白细胞抗原等位基因与HBV宫内感染关系 Association between HLA-DR alleles and HBV intrauterine infection Abstract： Objective To study the association between HLA-DR3,DR7,DR13,DR53 and HBV intrauterine infection to probe into the susceptibility to intrauterine infection of hepatitis B virus and to find its predisposing genes and protecting HLA-DR3,DR7,DR13,DR53 were detected by the technique of polymerase chain reaction-sequence specific prime(PCR-SSP) in maternal and neonatal blood (1) The frequency of HLA-DR was % in women with intrauterine infection,which was higher than that (%) in women without intrauterine infection(P=).There was no association between HLA-DR7,DR13,DR53 positive in pregnant women and HBV intrauterine infection(P).(2) The frequeney of HLA-R of newbor was % in women with intrauterine infection,which is higher that (%) in women withotll infection(P=).There was no association between HLA-DR7,DR13,DR53 positive in newbor and HBV intrauterine infection(P).(3)There was significant association between HLA-DR3 concordance and HBVintrauterine infection(P=).There was no association between DR7,DR13,DR53 concordance and HBV intrauterine infection(P).Conclusion HLA-DR3 carrie of pregnant women and their newbor have susceptibility to HBV intrauterine is the predisposing gene of HBV intrauterine infection. Key words： HBV；intrauterine infection；HLA-DR antigen 肝炎是一种严重危害人类健康的世界性传染病，我国是乙肝高发区，乙肝病毒的母婴传播不仅造成人群中众多的HBsAg携带者，而且是引起成人慢性肝炎、肝硬化以及肝癌的重要因素。迄今，多数学者认为，人类白细胞抗原DR等位基因(HLA-DR)与乙型肝炎病毒(HBV)感染密切相关，而HLA-DR等位基因与HBV宫内感染的关系争议较多。本文通过研究HLA-DR3、DR7、DR13、DR53与HBV宫内感染的关系，探讨HBV宫内感染的遗传易感性，为防制HBV宫内感染提供理论依据。 1 对象与方法 11 对象 以2003年6月～2004年11月太原市省各市级 医院 筛检，并在太原市传染病院妇产