文稿教程05医学免疫学08antigen presenting cells presentation.pptxVIP

chapterⅩⅣIMMUNOLOGYAntigen-Presenting Cells and Antigen PresentationWei ChenInstitute of Immunology, ZJU mailto:chenwei566@chenwei566@/566/566 Password: 8888Outline:What are APC and professional APC?Describe MHC class I and MHC class II presentation pathways. What are the physiological significances for these two pathway The difference between immature Dendritic Cell and mature DC.What is Cross presentation?What the function of CD1 molecule?Contents Introduction Antigen-presenting cellsAntigen processing and presentation MHC I-associated endogenous Ag presentation pathway MHC II-associated exogenous Ag presentation pathway Cross presentation CD1 presentation pathwayContents Introduction Antigen-presenting cellsAntigen processing and presentation MHC I-associated endogenous Ag presentation pathway MHC II-associated exogenous Ag presentation pathway Cross presentation CD1 presentation pathwayAntigen-presenting cell, APCA variety of cell types which can take up, process antigen and carry antigen in a form (antigenic peptide-MHC molecule complex) that can stimulate lymphocytes. Dendritic cells, monocytes/macrophages and B cells are professional APCs.The category of APCCells that express MHC class I, present endogenous antigenAre killed by CD8+ cellsAre called Target cellsCells that express MHC class II, present exogenous antigenActivate the CD4+ T cell responseAre called Antigen presenting cells Antigen presenting cellsProfessional APCs Dendritic cells, macrophages and B cells, which can express MHC class II molecules.Non-professional APC Endothelial cell (EC) Fibroblastic cell Activated T cellUnder some circumstances, they can express MHC II and present AntigenDendritic cellsMacrophagesB cellsAPC染色彩图Antigen-presenting cellsThe characteristics of APCsAntigen presentation The process by which certain cells in the body (APC) express antigen peptide-MHC molecule complex on their cell surface in a form recognizable by T lymphocytes.Antigen-presenting cells树突状细胞（Dendritic ce