骨折延迟愈合患者血转化生长因子.doc

骨折延迟愈合患者血转化生长因子 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：骨折延迟愈合患者血转化生长因子 1 1 材料与方法 3 2 结 果 4 3 讨 论 5 文2：体外冲击波治疗骨折延迟愈合的疗效观察 7 1 资料与方法 7 2 结 果 8 3 讨 论 9 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 13 正文 骨折延迟愈合患者血转化生长因子 文1：骨折延迟愈合患者血转化生长因子 Alteratio in Serum Level of TGFβ1 in Patients with Delayed Fracture Healing Abstract：Objective To determine the alteratio in serum level of TGFβ1 from patients with delayed fracture healing in comparison with those from normal All the 60 patients with delayed fracture healing were recruited as exp～imental group(Exp)and their peripheral blood samples were collected over a period of 1 yea following a standardized time 60 patients with normal healing were recruited as control group(Ctrl).The serum levels of TGFβ1 at 1，2，4，8，12，24，36，48，60 weeks after trauma were measured using enzyme immunoassays and compared between the 2 β1 in 30 patients with nonunion Was assayed pre，postoperation and after Serum levels of TGFβ1 increased significantly 2 weeks after fracture in both groups(P＜).During 2 to 4 weeks after trauma，TGFβ1 declined dramatically in Exp group to the reference value；but it still maintained at a relatively higher level in Ctrl group，about higher than Exp group(P＜).TGFβ1 in Ctrl group did not return to the reference value until 8 weeks after ，TGF13 1 in the patients with nonunion was similar to normal was a significant increase 2 weeks postoperation(P＜)，and a decrease 4 weeks Decline of serum concentration of TGFβ1 occurred earlier in patients with delayed fracture healing，which indicated that TGFβ1 plays a critical role in fracture also seems dependent on sufficient availability of TGFβ1 for patients with nonunion during coolidation words：delayed union；nonunion；fracture healing；TGFβ1 骨折愈合的生理过程不同于身体其他部位的组织再生，它最终需要重建骨折处的组织结构，使其恢复原有的生物学特征和功能，这一过程有部分类似于胚胎发育中的骨生成阶段［1］。近年来，随着免疫组织化学和基因表达等各方面的研究进展，发现在骨折愈合时必须有各种生化因子的参与，其中包括细胞因子、蛋白酶和血管形成因子［2］。在本研究中，我们通过对比骨折正常愈合和延迟愈合患者，以及骨不连患者手术前后外周血中转化生长因子(traforming growth fa