氟伐他汀对老年动脉粥样硬化所致肾动脉狭窄的疗效观察临床医学.docVIP

氟伐他汀对老年动脉粥样硬化所致肾动脉狭窄的疗效观察临床医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：氟伐他汀对老年动脉粥样硬化所致肾动脉狭窄的疗效观察临床医学 2 1 资料和方法 3 1．1 一般资料 3 1．2 治疗方法 3 1．3 观察指标 3 2 结果 4 21 对血压的影响 4 2．2 对UAER，Scr和CRP的影响 4 23 对PSV（cm），AT（s），RAR的影响 5 2．4 血脂正常的ARAS患者前后各指标比较 5 2．5 副作用 6 3 讨论 6 文2：肾动脉狭窄的介入治疗 7 1 材料与方法 8 2 结果 10 3 讨论 10 参考文摘引言： 12 原创性声明（模板） 12 文章致谢（模板） 13 正文 氟伐他汀对老年动脉粥样硬化所致肾动脉狭窄的疗效观察临床医学 文1：氟伐他汀对老年动脉粥样硬化所致肾动脉狭窄的疗效观察临床医学 Abstract： Objective To investigate the curative effects of fluvastin on atherosclerotic renal artery stenosis (ARAS) and its antiinflammation mechanism. Methods A total of 54 patients with ARAS were divided into two groups at random, . control group (n=27) and treatment group (n=27). The control group received conventional therapy, while the treatment group was given oral fluvastin (40 microgram) every night. Then, their UA excretion rate (UAER), serum creatinine (Scr) and Creaction protein (CRP) were measured three, six and nine months later, respectively, as well as PSV, AT and RAR. Results Facto such as UAER, Scr, PSV, AT and RAR decreased more significantly and quickly in the treatment group than in the control group (P, or P). CRP decreased significantly in the treatment group, while no significant decrease was found in the control group according to nine months followup. Furthermore, similar results were also obtained in those with ARAS with normal blood lipid level when further analysis was Fluvastin can meliorate microalbuminuria and inprove renal function by its antiinflammation effect via decreasing CRP, which is independent of its lowering lipid effect. Key words： atherosclerotic renal artery stenosis; fluvaatian; Creactive protein; Doppler ultrasound 动脉粥样硬化性肾动脉狭窄（atherosclerotic renal artery stenosis，ARAS）常发生于老年人，ARAS可以引起两种非常重要的疾病，即肾血管性高血压和缺血性肾病。ARAS和高血压、缺血性肾病的关系是非常复杂的［1］；高血压和缺血性肾病是导致终末期肾病的重要原因，终末期肾病可占老年高血压患者的10%~40%，纠正ARAS，部分病例不仅能纠正高血压，而且能保护受损的肾功能，使ARAS成为少有的老年人高血压和慢性肾功能不全的可治性病因之一［2］。本研究主要探讨在常规降压的