阻塞性睡眠呼吸暂停患者临床表现与上气道阻塞部位关系的探讨临床医学.docVIP

阻塞性睡眠呼吸暂停患者临床表现与上气道阻塞部位关系的探讨临床医学 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：阻塞性睡眠呼吸暂停患者临床表现与上气道阻塞部位关系的探讨临床医学 2 1 对象与方法 3 2 结果 5 3 讨论 6 文2：血液科层流隔离病房患者浅表部位病原菌分布临床医学 8 1 材料与方法 8 1．1 菌株来源 8 1．2 细菌、真菌的培养及鉴定试验 8 2 结 果 8 2．1 病原菌的检出率 8 2．2 血液病患者标本采集部位细菌检出率 9 2．3 病原菌的种类及构成比 9 3 讨 论 9 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 12 正文 阻塞性睡眠呼吸暂停患者临床表现与上气道阻塞部位关系的探讨临床医学 文1：阻塞性睡眠呼吸暂停患者临床表现与上气道阻塞部位关系的探讨临床医学 【Abstract】 Objective To investigate the effects of upper airway obstruction sites on polysomnographic paramete and clinical manifestatio in patients with obstructive sleep apnea syndrome (OSAS). Methods 36 adult male OSAS patients with their AHI between 30～40 were selected to undergo overnight PSG test and simultaneous pressure measurement of upper airway and esophagus for identification of the lowest upper airway obstruction sites. Comparison was made among different obstruction sites (sites of soft palate, tongue-base and lower pharynx) for the following paramete: nocturnal mean arterial oxyhemoglobin saturation (meaaO2) and minimal SpO2 (miniSaO2), the longest obstructive apnea event time, rate of fall of SaO2 (dSaO2/dt), arousal index; as well as some clinical manifestatio: day-time sleepiness scale, systolic blood pressure (SBP) at 9:00PM / SBP at 6:00AM, diastolic BP(DBP) at 9:00PM / DBP at 6:00AM and incidences of hyperteion. Results There was no significant difference of mean SpO2，the longest obstructive apnea event time and SBP at 9:00PM / SBP at 6:00AM (P) among three different lowest obstruction sites in OSAS patients. However, compared with the obstructive site at palate, the obstruction sites at tongue-base and lower pharynx displayed significant difference in the following PSG and clinical paramete: lower miniSaO2 (P),higher dSaO2/dt (P), higher arousal index and day-time sleepiness scale (P)，lower DBP at 9:00PM / DBP at 6:00AM. (P), higher incidence of miniSaO2 80% and hyperteion (all P).Conclusion In OSAS patients with similar A