铁甲草抑制二甲基亚硝胺诱导大鼠肝纤维化的实验研究.doc

铁甲草抑制二甲基亚硝胺诱导大鼠肝纤维化的实验研究 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：铁甲草抑制二甲基亚硝胺诱导大鼠肝纤维化的实验研究 1 1 材料与仪器 3 2 方法 4 3 结果 5 4 讨论 7 文2：春和丹治疗肝纤维化大鼠的实验研究 8 1 材料与方法 9 2 结果 10 3 讨论 12 参考文摘引言： 13 原创性声明（模板） 14 文章致谢（模板） 15 正文 铁甲草抑制二甲基亚硝胺诱导大鼠肝纤维化的实验研究 文1：铁甲草抑制二甲基亚硝胺诱导大鼠肝纤维化的实验研究 Abstract：ObjectiveThe aim of this study was to observe the inhibitive effects of the extract of Cassia mimosoides Linn. on dimethylnitrosamine-induced hepatic fibrosis in rats and to explore the action mechanism. MethodsIntervention treatment with the extract of Cassia mimosoides Linn. was explored in the rats with dimethylnitrosamine-induced hepatic fibrosis at the high, intermediate, and low doses of g/kg， g/kg，and g/kg respectively, compared with the group treated with colchicine. Hepatic function, levels of serum hyaluronic acid (HA), serum laminin (LN), serum aminoterminal propeptide of type III procollagen (PIIINP), hepatic hydroxyproline (Hyp) in rats were assayed and histopathological alteratio in rats were examined. ResultsThe results indicated that, compared with those in the model group, alteratio in the levels of serum alanine aminotraferase (ALT) in the groups treated with extract of Cassia mimosoides at low, intermediate, and high doses, and serum aspartate aminotraferase (AST) level in the group at the high dose were statistically significant (P); hepatic hydroxyproline (Hyp) levels in the rats treated with extract of Cassia mimosoides at various doses were significantly lower than those in the model group (P). Levels of serum hyaluronic acid (HA), serum laminin (LN), and serum aminoterminal propeptide of type III procollagen (PIIINP) in the groups treated with extract of Cassia mimosoides were significantly lower than those in the model group, and the differences were statistically significant (P). Hepatic fibrosis of rats in the groups treated with extract of Cassia mimosoides at high, intermediate, and low doses alleviated significantly, and the differ