2014技大三下课件基因组学理论课genetics.pptxVIP

第四节 数据库与数据检索 一、重要生物信息中心简介1．分子生物信息数据库发展简史2．分子生物信息数据库分类3．核酸序列数据库4．蛋白质序列数据库5．疾病相关基因数据库1．分子生物信息数据库发展简史60年代初， Dr. Margaret Oakley Dayhoff和她的同事们收集了所有当时已知的氨基酸序列，发表了《蛋白质序列及结构图谱》，建立了第一个生物信息数据库－－这一蛋白质数据库后来成为蛋白质信息资源PIR。Dr. Margaret Oakley Dayhoff (1925-1983) was a pioneer in the use of computers in chemistry and biology, beginning with her PhD thesis project in 1948.? Her work was multi-disciplinary, and used her knowledge of chemistry, mathematics, biology and computer science to develop an entirely new field.? She is credited today as a founder of the field of Bioinformatics.? This field is defined as