药物非房室模型分析.pptVIP

Application of Clearance Concepts Prediction of the effect of pathophysiological changes CLT = 1.2 L/hr Div = 500 mg Amount in urine unchanged = 63 mg 第三十一页，编辑于星期三：十五点 五十八分。 Mechanisms of altered elimination Verapamil has been shown to elevate serum digoxin concentrations in patients receiving both drugs concurrently. A study by Pedersen et al (Clin Pharmacol Ther 30:311-316, 1981.) examined this interaction with the following results.: Treatment Digoxin Dig + verapamil CLT 3.28 2.17 CLR 2.18 1.73 CLNR 1.10 0.44 第三十二页，编辑于星期三：十五点 五十八分。 STEADY-STATE VOLUME OF DISTRIBUTION Cf Cbp Cf C