关于平痫冲剂对戊四唑致痫大鼠颞叶谷氨酸受体和γ氨基丁酸受体的影响.doc

关于平痫冲剂对戊四唑致痫大鼠颞叶谷氨酸受体和γ氨基丁酸受体的影响 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：关于平痫冲剂对戊四唑致痫大鼠颞叶谷氨酸受体和γ氨基丁酸受体的影响 1 1 实验材料 3 2 实验方法 3 3 结果 5 4 讨论 5 文2：关于平痫冲剂对戊四唑致痫大鼠海马氨基酸类神经递质受体的影响 6 1 实验材料 7 2 实验方法 8 3 统计学方法 10 4 结果 10 5 讨论 10 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 13 正文 关于平痫冲剂对戊四唑致痫大鼠颞叶谷氨酸受体和γ氨基丁酸受体的影响 文1：关于平痫冲剂对戊四唑致痫大鼠颞叶谷氨酸受体和γ氨基丁酸受体的影响 Abstract：Objective To explore the possible antiepileptic mechanism of Pingxian Powder. Methods In the experiment， Pentylenetetrazole (PTZ) was injected into abdomen of rat to make epileptic kindling model. The total number， percentage of positive area and integral optical deity of N-methyl-D-aspartate receptor1 (NMDAR1) and γ-aminobutyric acid-A receptor (GABA-ARα1) of immunoreactive cells in the temporal cortex were studied by the immunohistochemical method and image analyzing system. Results The total number， percentage of positive area and integral optical deity of NMDAR1 of immunoreactive cells in the temporal cortex of model group were more than normal group (P)， while these numerical values of western and chinese medicine group decreased to varying degrees compared with model group (P， P). The total number， percentage of positive area and integral optical deity of GABA-ARα1 of immunoreactive cells in the temporal cortex of model group were less than nomal group (P)， while these numerical values of western and chinese medicine group enhanced to varying degrees cotrasting with model group (P， P). Conclusio Pingxian Powder may reduce the excitability of cerebral cortices by inhibiting the activities of NMDAR1 and promoting the activities of GABA-ARα1 in the temporal cortex to inhibit the formation and development of epilepsy。 Key words：epilepsy；Pingxian powder；Pentylenetetrazole (PTZ) kindling epileptic rat model；receptor 癫痫是一种常见的慢性脑部疾病，全世界约有4千万人受累。我国癫痫的患病率约为‰～‰，其中儿童癫痫的发病率约为成人的10倍，且半数以上在10岁以内起病[1]。该病严重影响患者的生活、工作、学习，且可能在发作时遭遇危险而危及生命，还会伴有一系列复杂的社会心理问题，给患者家庭及社会带来很大负担[2]。因此，如何正确、有效地防治癫痫已成为医学界尤其是