回阳生肌膏治疗慢性难愈性皮肤溃疡疗效观察及作用机制探讨.doc

回阳生肌膏治疗慢性难愈性皮肤溃疡疗效观察及作用机制探讨 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：回阳生肌膏治疗慢性难愈性皮肤溃疡疗效观察及作用机制探讨 1 1 资料与方法 2 2 结果 5 Ⅰ型胶原与Ⅲ型胶原比值及相关细胞因子表达 6 3 讨论 6 文2：皮粘散治疗慢性皮肤溃疡73例临床观察 7 1 临床资料 8 2 治疗方法 8 3 疗效观察 9 4 讨论 10 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 12 正文 回阳生肌膏治疗慢性难愈性皮肤溃疡疗效观察及作用机制探讨 文1：回阳生肌膏治疗慢性难愈性皮肤溃疡疗效观察及作用机制探讨 Abstract：Objective To research the curative effect of the chronic refractory skin ulcer， which belong to yang deficiency of both spleen and kidney type with the treatment of Huiyang Shengji ointment， and discuss the mechanism at cell and molecular level. Methods According to the diagnostic criteria， 102 patients were pided into the treatment group (treated with topical Huiyang Shengji ointment) and the control group (treated with topical chlorhexidine). The effects were summarized six weeks later. The marginal tissue of the patients with the chronic skin ulcer was taken to analyze collagen Ⅰ/Ⅲ with the software and the expression of cytokine FGF-2， VEGF， Fn were observed during the wound heal. Results The effective rate was 50% in the treatment group， the control group was %， with statistical differences. Huiyang Shengji ointment can change the status of the chronic wound， promote growth of new blood vessels and improve the collagen synthesis， especially collagenⅠ. The expression of the FGF-2 and VEGF in the marginal tissue of the chronic skin ulcer showed a rising trend. Conclusio Huiyang Shengji ointment can accelerate the wound heal of chronic refractory skin ulcer. One of the mechanisms is related to promoting growth of new blood vessels and improving the collagen synthesis。 Key words：Huiyang Shengji ointment；chronic refractory skin ulcer；FGF-2；VEGF 各类慢性皮肤溃疡，尤其是慢性难愈性溃疡是当前众多国内外学者关注的课题之一。回阳生肌膏是已故名医王玉章临证总结的有效方剂，长期用于慢性难愈性皮肤溃疡的治疗取得很好疗效。本研究拟在进一步考察其临床疗效，并对其疗效机制进行初步探讨。 1 资料与方法 病例来源及分组 所有病例为2002年7月－2007年12月首都医科大学附属北京中医医院外科病房及门诊的慢性皮肤溃疡患者，将符合诊断标准的患者随机分成治疗组、对照组进行治疗和观察。应用Excel软件以RAND函数产生的随机数字，编制随机分配卡，临床研究人员依照信封编号，开封取卡分组观察。治疗组(回阳生肌膏纱条)7