医学微生物学课件：13 人畜共患菌.pptx

Animal Source Bacteria(动物源性细菌); ; ;Zoonosis;Brucella (布鲁菌属); Brucella (布鲁菌属);Pathogenic strains for human being;Infectious routes;Pathogenesis;Disease;Human being: Brucellosis (undulant fever) Humans in closed contact with infected animals are at risk of developing undulant fever. The symptoms in brucellosis are due to the presence of the organism and appear 2 - 4 weeks (sometimes up to 2 months) after exposure. B. melitensis(羊布鲁菌 ) is the cause of most severe prolonged recurring disease. The intracellular persistence of bacteria results in granuloma(肉芽肿) formation in the reticuloendothelial system organs and tissue damage due to hypersensitivity reactions, mostly type-IV.;The bacteria are engulfed by neutrophils and monocytes and localize in the regional lymph nodes, where they proliferate intracellularly. The organisms migrate to other lympho-reticular organs (spleen, bone marrow, liver, testes) producing granulomas and/or micro abscesses. Symptoms include fever, chills, sweats, fatigue(疲劳), myalgia(肌痛), profound muscle weakness, and anorexia(厌食). ;Prevention and Treatment; Bacillus 芽胞杆菌属;B. Anthracis (炭疽芽胞杆菌);(一)Biological characteristics;culture;(二)Pathogenesis and immunity;Diseases---- anthrax Cutaneous anthrax (95%) Gastrointestinal anthrax (5%) Pulmonary anthrax (very rare) ;;(三) Diagnosis and prevention treatment;二.Yersinia 耶尔森菌属;Yersinia pestis 鼠疫耶尔森菌;Yersinia pestis 鼠疫耶尔森菌;Yersinia pestis grows well on most standard laboratory media, after 48-72 hours, grey-white to slightly yellow opaque raised, irregular “fried egg” morphology; alternatively colonies may have a “hammered copper” shiny surface ;Yersinia pestis 鼠疫耶尔森菌;Infectious source and routes;Disease;Plague patient displaying a swollen axillary lymph node;Prevention and treatment;Other bacteria;Nonfermentative gram-negative bacilli; Pseudomonas aeruginosa (铜绿假单胞菌) ;pathogenesis;pathogenesis; Helicobacter pylori, HP (幽门螺杆菌);1997年9月2日，沃伦（右）和马歇尔在澳大利亚珀斯市 ; Helicobacter pylori, HP