脂肪内分泌学课件.pptxVIP

脂 肪 内 分 泌 学;人类的进化;脂肪因子的概念 ;Ebstain W(1876)、Williamson RT(1901)医生应用水杨酸钠(5-7g/d)，显著降低DM患者尿糖 Reid J(1957)用aspirin(6g/d)治疗DM合并RA患者，该患者血糖恢复正常 Hotalmisligil GS(1993) 研究发现脂肪细胞表达和分泌TNFa。A key component of between Obesity DM Shoelson S(2002)进一步证实Reid的假说，并发现NSAID抑制了 IKK/NF-kB通路 Marette A(2003)：肥胖是一种慢性炎症性疾病;;临床流行病学研究;胰岛素输注对 NFkB 及IkBa 的影响;胰岛素抑制炎症因子生成;(Diabetes 2002;51:2005-2011);0;(Diabetes 2002;51:2005-2011) ;(Diabetes 2002;51:2005-2011) ;(J Clin Endocrinol Metab 2001;86:1306-1312) ;IKKa抑制剂、PP2A抑制剂和TZD对高脂喂养大鼠代谢的影响;IKKa抑制剂、PP2A抑制剂和TZD对高脂喂养大鼠代谢的影响;TNF, IL-6 and insulin resistance ;;脂肪因子的概念 ;TGF?;脂肪组织特异表达的脂肪因子;IL-18 　　 ``Increased 3T3-L1 adipocytes glucose uptake Visfatin　　 `` a protein predominantly secreted by visceral fat that mimics the effects of insulin.;;1=NGT 2=Ob 3=IGT 4=T2DM;脂肪因子的概念 ;脂联素 Adiponectin;Adiponectin Source;水平降低与以下相关 向心性肥胖和胰岛素抵抗 2型糖尿病 高TG和sd-LDL 冠心病 水平增加则： HDL 增加 胰岛素敏感性增加;脂联素与SI和AIRg的相关性研究;576bp ;P0.05;Adiponectin: a pleiotropic adipocytokine;脂肪因子的概念 ;TNF?;TNF?;A B C D E F G H I J K L M N O P;Marker;;IL-18与胰岛素敏感性的相关性;R=-0.405 P=0.009;0;PCOS患者的IL-18水平显著升高；且由钳夹试验测得的反映胰岛素敏感性的各值与IL-18浓度间显著负相关 可促进3T3-L1脂肪细胞胰岛素刺激的葡萄糖转运即胰岛素抵抗改善 TZD可降低IL-18水平;脂肪因子的概念 ;Hug et al, science, 2005;Visfatin又称前B细胞克隆增强因子（PBEF）;Visfatin 在人和小鼠的内脏脂肪组织高表达;EXPRESSION OF VISFATIN;杂合子小鼠血糖水平较高;Visfatin 能够模拟胰岛素降低小鼠的血糖;Serum visfatin increases with progressive B-cell deterioration;Visfatin与胰岛素的不同点;The association between adiponectin and T2DM was no longer significant after adjustments for BMI or WHR. Only WHR was independently associated with plasma visfatin level;Elevated plasma level of visfatin in patients with type 2 diabetes ;Serum visfatin increases with progressive B-cell deterioration;Cytokine expression in human leukocytes;Visfatin in IBD: Serum level and tissue expression;Liver visfatin expression after severe weight loss;Modulation of Visfatin;VISFATIN FUNCTION;SOME DOUBTS ABOUT VISFATIN;结语;谢谢