蛋白酶抑制剂对原位肝移植术中促炎性细胞因子和氧自由基代谢的影响（论文资料）.docVIP

蛋白酶抑制剂对原位肝移植术中促炎性细胞因子和氧自由基代谢的影响（论文资料） 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：蛋白酶抑制剂对原位肝移植术中促炎性细胞因子和氧自由基代谢的影响 1 2 结果 4 3 讨论 5 文2：蛋白酶抑制剂对原位肝移植术中促炎性细胞因子和氧自由基代谢的影响 7 2 结果 10 参考文摘引言： 10 原创性声明（模板） 12 文章致谢（模板） 12 正文 蛋白酶抑制剂对原位肝移植术中促炎性细胞因子和氧自由基代谢的影响（论文资料） 文1：蛋白酶抑制剂对原位肝移植术中促炎性细胞因子和氧自由基代谢的影响 effects of ulinastatin on proinflammatory cytokines and oxygen free radicals during orthotopic liver traplantation feng guo-hui，lei zhi-li，yu peng，et of anesthesia，general hospital of chinese people’s armed police forces，beijing 100039，china ［abstract］ objective to evaluate the effects of ulinastatin on proinflammatory cytokines and oxygen free radical during orthotopic liver traplantation(olt).methods twenty asa ⅲ～ⅳ patients with end-stage liver diseases，undergoing olt were randomly divided into two group received intravenous infusion of ulinastatin 3×105iu in 100ml normal saline after skin incision and every 4 hou thereafter(n=10).control group received same amount of normal saline itead of ulinastatin(n=10).blood samples were taken before skin incision(t0)，120min after skin incision(t1)，30min after liver was removed(t2)，5min (t3) and 60min (t4) after reperfusion of the graft and at the end of operation (t5)for determination of plasma il-6，il-8，tnf-α，mda concentration and sod anesthesia induced，cardiac output，mixed venous oxygen saturation and central venous temperature were continuously monitored during ，cvp，spo2，petco2，radial artery and mpap were also continuously monitored during was maintained at (35～40)mmhg during temperature was maintained above ℃ during two group plasma il-6 and il-8 concentratio were significantly increased from t2 to t5 as compared with the baseline values(p＜)，whereas plasma levels of tnf-α were significantly increased from t1 to t5 and compared with in the group c plasma tnf-α，il-6 and il-8 concentratio were significantly group plasma mda did not change significantly before and during anhepatic phase but were significantly incr