口服降糖药的选择与联合应用.pptVIP

UKPDS 33：强化治疗达标的主要障碍是低血糖 HbA1c (%) 每100病人年发生严重低血糖的病例数 0 10 20 30 40 50 60 70 80 90 100 6 6.5 7 7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 常规 强化 UKPDS 33: Lancet 1998;352:837–53 * . 7 6 9 8 HbA1c (%) 10 OAD monotherapy Diet OAD combination OAD + basal insulin OAD monotherapyuptitration Duration of diabetes OAD + multiple dailyinsulin injections 常规续贯治疗不利于血糖达标 * . OAD + basal insulin OAD + multiple daily insulin injections Diet OAD monotherapy OAD combinations OADs uptitration Duration of diabetes 7 6 9 8 HbA1c (%) 10 早期联合治疗更利于血糖达标 * . 2型糖尿病联合治