去甲基化药物联合CAG方案治疗老年急性髓系白血病的效果.docxVIP

去甲基化药物联合CAG方案治疗老年急性髓系白血病的效果 　　[摘要]目的探讨去甲基化药物联合cag方案治疗老年急性髓系白血病的效果。方法回顾性分析我院2013年6月～2018年6月收治的62例老年急性髓系白血病患者，根据治疗方法的不同分为对照组（34例）与观察组（28例）。对照组患者接受cag方案（阿克拉霉素+阿糖胞苷+粒细胞集落刺激因子）治疗，观察组患者接受去甲基化药物+cag方案治疗，比较两组患者的临床治疗效果及不良反应情况。结果观察组患者的治疗总有效率为75.00%，明显高于对照组的55.88%，差异有统计学意义（p0.05）。两组患者的肺部感染、心力衰竭、恶心呕吐、肝功能损伤、血小板减少及粒细胞减少发生率比较，差异无统计学意义（p0.05）。结论对老年急性髓系白血病患者予以去甲基化药物+cag方案治疗的临床效果较好，且安全性可靠，未增加患者出现并发症的概率，值得临床推广应用。 　　[关键词]老年急性髓系白血病；去甲基化药物；cag方案 　　[中图分类号]r552[文献标识码]a[文章编号]1674-4721（2019）4（c）-0061-03 　　effectofdemethylateddrugscombinedwithcagregimeninthetreatmentofacutemyeloidleukemiaintheelderly 　　liwei-huaguozi-wenhehui-qingniuxiao-minliwei-chao 　　departmentofhematology，people′shospitalofzhongshancityinguangdongprovince，zhongshan528400，china 　　[abstract]objectivetoexploretheeffectofdemethylationagentscombinedwithcagregimeninthetreatmentofacutemyeloidleukemiaintheelderly.methodsatotalof62casesofelderlypatientsadmittedforacutemyeloidleukemiainourhospitalfromjune2013tojune2018wereretrospectivelyanalyzed，accordingtothedifferenttreatmentmethods，theyweredividedintothecontrolgroup（34cases）andtheobservationgroup（28cases）.thepatientsinthecontrolgroupweretreatedwithcagregimen，whilethoseintheobservationgroupweretreatedwithdemethylationdrugspluscagregimen（aclacinomycin+cytarabine+granulocytecolonystimulatingfactor）.theclinicalefficacyandadversereactionsofthetwogroupswerecompared.resultsthetotaleffectiverateoftheobservationgroupwas75.00%，whichwassignificantlyhigherthan55.88%ofthecontrolgroup，thedifferencewasstatisticallysignificant（p0.05）.therewasnosignificantdifferenceintheincidenceofpulmonaryinfection，heartfailure，nauseaandvomiting，liverfunctiondamage，thrombocytopeniaandgranulocytopeniabetweenthetwogroups（p0.05）.conclusiontheclinicaleffectofdemethylationdrugpluscagregimeninthetreatmentofelderlypatientswithacutemyeloidleukemiaisgood，anditissafeandreliable.itdoesnotincreasetheprobabilityofcomplications.itisworthyofclinicalpromotionandapplication. 　　[keywords]acutemyel