医学免疫学课件：IFN-1抗病毒效应的细胞分子机制.pptxVIP

Cell and Molecular Mechanisms of IFN-1 in Anti-viral Immunity;CONTENT：;IFN Related Basic Knowledge:;IFN-1 Production and Regulation;IFN-1 Production in Infected Cells：;Virus Entry Inducing IFN-1 through STING-dependent Signaling:;Virus Uncoating : IFN-1 Production initiated by I2R2s detection of Viral Nucleotide;Virus Uncoating: RNA Sensor Pathway;Virus Uncoating: DNA Sensor Pathway;Virus Uncoating: DNA Sensor Pathway;Virus Uncoating: DNA Sensor Pathway;Viral Translation Causes UPR Response Inducing IFN-1 Production;IFN-1 Production in Uninfected Cells：;pDCs versus XCR1+ DCs:;IFN-1 Production mechanisms in Uninfected Cells：;Positive And Negative Regulations of IFN-1 Production;Positive Feedback loops of IFN-1 Production:;IRF7 Positive Feedback Loop:;Negative Feedback loops of IFN-1 Production:;Negative Feedback loops of IFN-1 Production:;Negative Feedback loops of IFN-1 Production:;Positive and Negative Regulations Integration in IFN Production;IFN-1 Functions in Anti-viral Immunity;IFN-1 Functions in Anti-viral Immunity;IFN-1 Direct Anti-viral Effectors Functions in Cell-intrinsic Anti-viral Immunity;IFN-signaling cascades inducing ISGs expression;IFN-signaling cascades inducing ISGs expression;ISG Expressed Anti-viral Effectors Counteracting Virus Infection：;IFN-1 Stimulate Anti-viral Responses of T cells:;IFN-1 Stimulate Anti-viral Responses of T cells:;Perspectives for future studies:;REFERENCES:;THANK YOU