医学免疫学课件：C反应蛋白与动脉粥样硬化.pptxVIP

C反应蛋白（CRP）和 动脉粥样硬化（AS）;C反应蛋白（CRP） 简介 结构 动脉粥样硬化（AS） 简介 组织学 与CRP相关的发病机制 巨噬细胞 血管内皮功能紊乱 LDL的转胞作用 其他 mCRP 展望 参考文献 ;CRP——简介;C-reactive protein at the interface between innate immunity and inflammation. EXPERT REVIEW OF CLINICAL IMMUNOLOGY 2008 4;3:379-390;AS——简介;Otsuka F, Yasuda S, Noguchi T, et al. Pathology of coronary atherosclerosis and thrombosis.[J]. Cardiovascular Diagnosis Therapy, 2016, 6(4):396-408. ;巨噬细胞 血管内皮功能紊乱 LDL的转胞作用 其他 mCRP ;CRP与巨噬细胞;Singh U, Dasu M R, Yancey P G, et al. Human C-reactive protein promotes oxidized low density lipoprotein uptake and matrix metalloproteinase-9 release in Wistar rats.[J]. Journal of Lipid Research, 2008, 49(5):1015-23. ;Singh U, Dasu M R, Yancey P G, et al. Human C-reactive protein promotes oxidized low density lipoprotein uptake and matrix metalloproteinase-9 release in Wistar rats.[J]. Journal of Lipid Research, 2008, 49(5):1015-23. ;FC：free cholesterol EC：cholesteryl ester;Singh U, Dasu M R, Yancey P G, et al. Human C-reactive protein promotes oxidized low density lipoprotein uptake and matrix metalloproteinase-9 release in Wistar rats.[J]. Journal of Lipid Research, 2008, 49(5):1015-23. ;CRP与巨噬细胞;巨噬细胞 血管内皮功能紊乱 LDL的转胞作用 其他 mCRP ;Matsuzawa Y, Lerman A. Endothelial dysfunction and coronary artery disease: assessment, prognosis, and treatment.[J]. Coronary Artery Disease, 2014, 25(8):713-24. ;CRP与血管内皮功能紊乱;Hein T W, Singh U, Vasquez-Vivar J, et al. Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo.[J]. Atherosclerosis, 2009, 206(1):61-8. ;Hein T W, Singh U, Vasquez-Vivar J, et al. Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo.[J]. Atherosclerosis, 2009, 206(1):61-8. ;Hein T W, Singh U, Vasquez-Vivar J, et al. Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo.[J]. Atherosclerosis, 2009, 206(1):61-8. ;Hein T W, Singh U, Vasquez-Vivar J, et al. Human C-reactive protein induces endothelial dysfunction and uncoup