医学免疫学课件：CD分子.pptxVIP

A Brief Introduction of  CD Antigen;Outline ;Cluster of Differentiation Antigen; ;;Nomenclature Rule ;Classification of CD;“包罗万象” “博大精深” Complicated interactions with various molecules Cooperate to function properly and efficiently Uncertified roles in precise regulation of immune system Etc. ;MOST wide-discussed molecules;CD3;CD3;;;Function- CD3;CD4;CD4 structure;Intracellular tail (C): special sequence of amino acids interact with the lck Lck( kinase): Tyrosine-phosphorylate the immunoreceptor tyrosine activation motifs (ITAM) Amplify the signals GET various Th cell;;Function;Recent view of CD4;Zhen A, et al. CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.[J]. Journal of Virology, 2014, ;CD8;Structure;Functions;Recent view of CD8;Summary;Outlook;Reference ;P D, Kwong, R, Wyatt, J, Robinson, et al. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.[J]. Nature, 1998, 393(6686):648-59. Gao G F, Jakobsen B K. Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with the T-cell receptor[J]. Immunology Today, 2000, 21(12):630-636. Ellmeier W. Molecular control of CD4+ T cell lineage plasticity and integrity.[J]. International Immunopharmacology, 2015. 崔健, 肖鹤, 冯健男,等. CD4分子功能表位及拮抗剂研究进展[J]. 军事医学, 2007, 31(02):170-174. 胡迪超, 张爱华, 杨晓明. 人CD4分子及其治疗性抗体的研究进展[J]. 中国生物制品学杂志, 2010, 23(08):896-900. 李乙江, 赵娜, 郭彦,等. CD3分子的研究进展[C]// 中国畜牧兽医学会家畜传染病学分会第七届全国会员代表大会暨第十三次学术研讨会论文集（上册）. 2009.;Thanks for attention