医学免疫学课件:kidney transplantation rejection.pptxVIP

医学免疫学课件:kidney transplantation rejection.pptx

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Kidney transplantation graft rejection;Outline;Transplantation;Classification of transplantation;Kidney transplantation;Graft rejection (host vs graft);Antibody-mediated rejection;Mechanisms of ABMR;Antigens ( MHC );Antigens ( non-MHC );Antibodies;Diagnosis;Detection of DSAs;Cell-based assay;Solid-phase antibody detected assay;Comparisons ;Detection of C4d;Classification of ABMR;Hyper-acute ABMR;For ABO incompatible patients;Acute ABMR;Complement activation;Chronic ABMR;Stegall MD, etc. Nat Rev Nephrol - November 1, 2012; 8 (11); 670-8, figure 1. ;Treatments;Treatments ;Future;Future;Opinion ;References;Significance of the positive crossmatch test in kidney transplantation. Patel R, Terasaki PI - N. Engl. J. Med. - April 3, 1969; 280 (14); 735 -9. The role of complement in antibody-mediated rejection in kidney transplantation. Stegall MD, Chedid MF, Cornell LD - Nat Rev Nephrol - November 1, 2012; 8 (11); 670-8. Molecular diagnosis of antibody-mediated rejection in human kidney transplants. Sellarés J, Reeve J, Loupy A, Mengel M, Sis B, Skene A, de Freitas DG, Kreepala C, Hidalgo LG, Famulski KS, Halloran PF - Am. J. Transplant. - April 1, 2013; 13 (4); 971-83. Antibody-mediated rejection in renal allografts: lessons from pathology. Racusen LC, Haas M - Clin J Am Soc Nephrol - May 1, 2006; 1 (3); 415-20. Olivia R. Blume, Sarah E. Yost, Bruce Kaplan, Antibody-Mediated Rejection: Pathogenesis, Prevention, Treatment, and Outcomes, Journal of Transplantation Volume 2012. Mengel M, Sis B, Haas M, et al. Banff 2013 meeting report: Banff 2013 Meeting Report: Inclusion of C4d-Negative Antibody-Mediated Rejection and Antibody-Associated Arterial Lesions .Am J Transplant 2014; 14: 272–283 Brian J. Nankivell,Stephen I. Alexander, Rejection of the Kidney Allograft, N Engl J Med 2010;363:1451-62. ;Thank you for listening!

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