医学免疫学课件：NK细胞与HCV.pptxVIP

2016 Natural Killer cells in Hepatitis C Virus infection 1. Background 2. NK cells in the defense against HCV infection · HCV infection · NK cells · Activation of NK cells - kIR · How does NK cell work in HCV infection? · NK cells response in every stage of HCV infection · Conventional treatment · NK cell memory 3. Treatment of HCV infection -focus on NK cells 4. Problems and Challenges estimated 170 million people average prevalence 3% developed country 2% estimated 15 million people prevalence 3.2% higher growth rate than HBV Yellow book, Chapter 3, Hepatitis C, Centers for Disease Control and Prevention,July 10, 2015 Map1. Global epidemiology of Hepatitis C virus infection Structure · positive-sense single-stranded RNA · protective protein shell， lipid envelope · envelope glycoproteins, E1 and E2 Hepatitis C virus Bloodborne virus · injecting drug use（IDU） · the reuse of medical equipment · the transfusion of unscreened blood sexually and congenitally，low rate Park, Su-Hyung et al.. Immune Responses to HCV and Other Hepatitis Viruses. Immunity , 2013, Volume 40 , Issue 1 , 13 - 24  A leading cause of end-stage liver diseases throughout the world the most common reason for liver transplantation in Western countries Hepatitis C virus infection 15-45% 55-85% 55-85% Park, Su-Hyung et al.. Immune Responses to HCV and Other Hepatitis Viruses. Immunity , 2013, Volume 40 , Issue 1 , 13 - 24 Natural Killer Cell · 90% in hepatopathy · Three distinct NK cell subsets CD56brightCD16 - , CD56dimCD16+ ，CD56-CD16+ · lack antigen-specific cell surface receptors · Cytotoxicity lyse cell by Perforin and granzymes · Cytokines IFN-γ，IL，TNF-β .etc Lee, Jaewon et al. Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals. Immunity , 2015,Volume 42 , Issue 3 , 431 - 442 NK cells in response to infected cell，Science photo library Natural Killer Rece