Chapter16抗帕金森病药.ppt

Chapter 16抗帕金森病药Antiparkinsonism Drugs; Muhammad Ali, the greatest boxer who suffers from parkinsonism, lit the Olympic flame at the 1996 Summer games in Atlanta ...;Origin of Parkinson disease ;Pakinson disease, 也称震颤麻痹 病变部位： 黑质 － 纹状体 (substantia nigra) (striatum) 病因：黑质－纹状体内多巴胺神经功能障碍;DA神经元胞体位于黑质，末梢终止于纹状体：黑质-纹状体束，全脑的DA约80%集中于该处; Pathogenesis ;黑质-纹状体 ;帕金森病/帕金森综合征动物模型;;;Sketch map of PD;Medical Therapies of PD; PD四组征候群 ⑴ 静止性震颤 (resting tremor) ⑵ 肌肉僵直 (rigidity)：肌张力增强 运动困难、