Etelcalcetide-AMG-416-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Etelcalcetide Cat. No.: HY-P1955 CAS No.: 1262780-97-1 Synonyms: AMG 416; KAI-4169 分⼦式: C₃₈H₇₃N₂₁O₁₀S₂ 分⼦量: 1048.25 Sequence: {Cys1}-Ac-{d-Cys1}-{d-Ala}-{d-Arg}-{d-Arg}-{d-Arg}-{d-Ala}-{d- Arg}-NH2 (Disulfide bridge: Cys1-Cys1) Sequence Shortening: C-Ac-d-C-d-A-d-R-d-R-d-R-d-A-d-R-NH2 (Disulfide bridge: Cys1-Cys1) 作⽤靶点: CaSR 作⽤通路: GPCR/G Protein 储存⽅式: Please store the product under the recommended conditions in the COA. BIOLOGICAL ACTIVITY ⽣物活性 Etelcalcetide (AMG 416) 是⼀种合成肽，有钙敏感受体 (CaSR) 活化剂的作⽤。Etelcalcetide 可有效降低接受 ⾎液透析的继发性甲状旁腺功能亢进患者的 甲状旁腺激素 (PTH) 浓度。 REFERENCES [1]. Block GA, et al. Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. JAMA. 2017 Jan 10;317(2):156-164. McePdfHeight Caution: Product has not been fully validated for medical applications. For research use only. Tel: 400-820-3792; 021-589