细菌检查和耐药监测在抗菌药物合理应用中的作用.pptVIP

Specific issues for each class. Mainly focus on ?-lactamases Won’t cover cephamycins and aztreonam because not used as often in most places Will explain broad spectrum ?-lactamases a bit more in next slide Solution applies to all ?-lactamase problems – use a drug not inactivated by these ?-lactamases to take out pathogens developing resistance Ancestors of some ESBLs The problem was that when 2 and 3 gen cephalosporins were used overcome resistance caused by these ?-lactamases, they kept on being used and used and used – creating an enormous selection pressure in which tons of these antib