东莞地区老年人高脂血症ApoE基因多态性与血脂水平相关性探讨（基础医学范文）.docVIP

东莞地区老年人高脂血症ApoE基因多态性与血脂水平相关性探讨（基础医学范文） 目录 TOC \o 1-9 \h \z \u 目录 1 正文 1 文1：东莞地区老年人高脂血症ApoE基因多态性与血脂水平相关性探讨 1 文2：ApoE基因多态性与疾病关系研究进展 6 1 ApoE基因多态性及生化基础 7 2 ApoE基因多态性与疾病的关系 8 3 结语 11 参考文摘引言： 12 原创性声明（模板） 13 文章致谢（模板） 14 正文 东莞地区老年人高脂血症ApoE基因多态性与血脂水平相关性探讨（基础医学范文） 文1：东莞地区老年人高脂血症ApoE基因多态性与血脂水平相关性探讨 DOI：10.14163/j.cnki.11-5547.2018.11.014 【Abstract】 Objective To discuss the correlation between Apolipoprotein E （ApoE） gene polymorphism and blood lipid level in the elderly hyperlipidemia patients in Dongguan. Methods There were 2100 hyperlipidemia patients as hyperlipidemia group， and 100 healthy control peo as control group. ApoE genotypes in both groups were detected by polymerase chain reaction restriction fragment length polymorphism （PCR-RFLP） method， and triglyceride （TG）， total cholesterol （TC）， low deity lipoprotein cholesterol （LDL-C）， high deity lipoprotein cholesterol （HDL-C） level were detected by automatic biochemical analyzer. Its correlation with ApoE gene polymorphism was analyzed. Results Six genotypes of E2/2， E3/3， E4/4， E2/3， E2/4 and E3/4 were detected in two groups. The frequency of E3/3 genotype in the hyperlipidemia group was lower than that in the control group， and the frequency of E3/4 genotype was higher than that in the control group （P0.05 or 0.01）. Patients with E3/4+ E4/4 genotype had obviously higher E3/3 and E2/2+ E2/3 genotype， and lower HDL-C level than patients with E2/2+ E2/3 genotype. Their difference was statistically significant （P0.05）. Patients with E3/3 genotype had higher LDL-C level than patients with E2/2+ E2/3 genotype， and the difference was statistically significant （P0.05）. Conclusion There is a correlation between ApoE gene polymorphism and hyperlipidemia. The E3/4+ E4/4 genotype is positively correlated with TC and LDL， and E3/3 and E2/2+ E2/3 are negatively correlated. 【Key words】 Apolipoprotein E； Polymorphism； Hyperlipidemia； Correlation 高脂血?Y是老年人冠心病的重要危险因素， ApoE是一种多态性蛋白， 有三个常见的异构体， 主要分布于乳糜微粒（C