AMY-101-acetate-Cp40-acetate-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE AMY-101 acetate Cat. No.: HY-P1717B Synonyms: Cp40 acetate 分⼦式: C₈₅H₁₂₁N₂₃O₂₀S₂ 分⼦量: 1849.16 Sequence: Tyr-Ile-Cys-Val-{Trp(Me)}-Gln-Asp-Trp-{Sar}-Ala-His-Arg-Cys-{ N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13) Sequence Shortening: YICV-{Trp(Me)}-QDW-{Sar}-AHRC-{N(Me)Ile}-NH2 (Disulfide bridge:Cys3-Cys13) 作⽤靶点: Complement System; SARS-CoV 作⽤通路: Immunology/Inflammation; Anti-infection 储存⽅式: Protect from light Powder -80°C 2 years -20°C 1 year In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 AMY-101 acetate (Cp40 acetate) 是补体 C3 的肽类抑制剂 (KD = 0.5 nM)，可抑制⾮⼈类灵长类动物⾃然发⽣ 的⽛周炎。AMY-101 acetate (Cp40 acetate) 在 COVID-19 重症肺炎合并全⾝超炎症模型中具有良好的抗炎活 性。 IC50 & Target KD: 0.5 nM (C3) [1]. 体内研究 AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis [1]. AMY-101 can induce a long-lasting anti-inflammatory effect [1]. AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction [1].