Antimycin-A1-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Agonists • Screening Libraries www.MedChemE Antimycin A1 Cat. No.: HY-107406 CAS No.: 642-15-9 分⼦式: C₂₈H₄₀N₂O₉ 分⼦量: 548.63 作⽤靶点: Mitochondrial Metabolism 作⽤通路: Metabolic Enzyme/Protease 储存⽅式: Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 Antimycin A1 是泛醇-细胞⾊素 c 氧化还原酶的特定电⼦转移 (electron transfer) 抑制剂。Antimycin A1 通过 抑制 HIF-1 α 激活导致的 VEGF 产⽣减少来抑制⾎管⽣成。 体外研究 Antimycin A, a mixture of Antimycins A1, A2, A3, and A4, is an antibiotic produced by Streptomyces species and displays antifungal, insecticidal, nematocidal, and piscicidal properties [3]. Antimycin A inhibits Bcl-2 and Bcl-xL proteins, inducing apoptosis [4]. REFERENCES [1]. Hoeon Kim, et al. Structure of Antimycin A1, a Specific Electron Transfer Inhibitor of Ubiquinol-Cytochrome c Oxidoreductase. J. Am. Chem. Soc. 1999, 121, 20, 4902-4903. [2]. Maeda M, et al. Inhibition of angiogenesis and HIF-1alpha activity by antimycin A1. Biol Pharm Bull. 2006;29(7):1344-1348. [3]. Liu J, et al, Bio