FAAH-MAGL-IN-2-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE FAAH/MAGL-IN-2 Cat. No.: HY-143264 分⼦式: C₁₅H₁₃Cl₂N₃O₃S 分⼦量: 386.25 作⽤靶点: FAAH; MAGL 作⽤通路: Metabolic Enzyme/Protease; Neuronal Signaling 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 FAAH/MAGL-IN-2 是⼀种有效的，可逆的，具有⼝服活性且可透过⾎脑屏障的 FAAH 和 MAGL 抑制剂，其IC50 值分别为 11 nM 和 36 nM (bKi 值分别为 28 nM 和 60 nM)。FAAH/MAGL-IN-2 有治疗神经性疼痛的潜⼒⽽不 引起运动障碍 [1]。 IC50 Target IC50: 11 nM (FAAH); 36 nM (MAGL) [1] 体外研究 FAAH/MAGL-IN-2 (compound 14) (1, 3, 10, 30, 100 μM) shows potent neuroprotection effect [1]. Cell Cytotoxicity Assay [1] Cell Line: SH-SY5Y cells Concentration: 1, 3, 10, 30, 100 μM Incubation Time: 24 h Result: Showed potent neuroprotection effect. 体内研究 FAAH/MAGL-IN-2 (10 mg/kg) has the potential to produce a significant anti-nociceptive effect without affecting of motor coordination and locomotor activity [1]. FAAH/MAGL-IN-2 (5, 10, 20 mg/kg) has the potential to treat neuropathic pain without causing locomotion impairment [1]. FAAH/MAGL-IN-2 (2000 mg/kg; p.o.; female rats) shows