FLT3-IN-11-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE FLT3-IN-11 Cat. No.: HY-143894 CAS No.: 2499966-50-4 分⼦式: C₂₀H₂₅F₃N₆O 分⼦量: 422.45 作⽤靶点: FLT3 作⽤通路: Protein Tyrosine Kinase/RTK 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 FLT3-IN-11 (compound 30) 是⼀种有效、选择性和具有⼝服活性的 FLT3 激酶抑制剂，对野⽣型 FLT3 和 FLT3- D835Y 的 IC50 分别为 7.22 nM 和 4.95 nM。FLT3-IN-11 对 FLT3 的选择性⾼于 c-KIT (1000 倍)。FLT3-IN-11 具有出⾊的抗急性髓性⽩⾎病 (AML) 活性 (MV4-11 细胞，IC50 为 3.2 nM)。 IC50 Target IC50: 7.22 nM (wild-type FLT3) and 4.95 nM (FLT3-D835Y) [1] 体外研究 FLT3-IN-11 (compound 30) efficiently inhibits the growth of multiple mutant BaF3 cells expressing FLT3-ITD, FLT3-D835V/F, FLT3-F691L, FLT3-ITD-F691L, and FLT3-ITD-D835Y [1]. 体内研究 Oral administration of FLT3-IN-11 (compound 30) at 6 mg/kg/d could significantly suppress tumor growth in the MV4-11 cell-inoculated xenograft model, exhibiting tumor growth inhibitory rates of 83.5% [1]. REFERENCES [1]. Lexian Tong, et al. Identification of 2-Aminopyrimidine Der