Nullscript-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Nullscript Cat. No.: HY-118421 CAS No.: 300816-11-9 分⼦式: C₁₆H₁₄N₂O₄ 分⼦量: 298.29 作⽤靶点: Parasite; HDAC 作⽤通路: Anti-infection; Cell Cycle/DNA Damage; Epigenetics 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Nullscript 是 Scriptaid 的阴性对照。 Nullscript 是 Scriptaid的⾮活性类似物 [1]。 Scriptaid 是⼀种具有代表性 的 HDAC 抑制剂 [2]。 Nullscript 抑制 Cryptosporidium (C. parvum) ⽣长，IC50 值为 2.1 μM [3]。 REFERENCES [1]. Min Tong, et al. Histone deacetylase inhibitors and transforming growth factor-beta induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells. Biochem Pharmacol. 2006 Sep 14;72(6):701-9. [2]. Judith Clancy Keen, et al. A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2-deoxycytidine. Breast Cancer Res Treat. 2003 [3]. Fumi Murakoshi, et al. Nullscript inhibits Cryptosporidium and Toxoplasma growth. Int J Parasitol Drugs Drug Resist. 2020 Dec;14:159- 166. Mce