MMI-0100-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE MMI-0100 Cat. No.: HY-P3412 CAS No.: 1039342-24-9 分⼦式: C₉₈H₁₇₁N₃₇O₂₆ 分⼦量: 2283.64 Sequence Shortening: YARAAARQARAKALARQLGVAA 作⽤靶点: MAPKAPK2 (MK2) 作⽤通路: MAPK/ERK Pathway 储存⽅式: Protect from light, stored under nitrogen Powder -80°C 2 years -20°C 1 year In solvent -80°C 6 months -20°C 1 month BIOLOGICAL ACTIVITY ⽣物活性 MMI-0100 是⼀种细胞渗透性肽抑制剂，抑制丝裂原活化蛋⽩激酶活化蛋⽩激酶 II (MK2)。MMI-0100 在体内 外减少内膜增⽣。MMI-0100 抑制 IL-6 表达⽽不影响 IL-8 表达。MMI-0100 抑制纤维化过程，例如静脉移植疾 病 [1]。 体外研究 Naphthofluorescein (compound 19) (0-10 μM; 24 hours) suppresses the HIF-1 reporter activity in a concentration-dependent manner. [1]. MMI-0100 (0.25 and 0.5 mM; 24 hours) slightly increases cell proliferation in both cell types compared to control cells treated with 20 ng/ml TNF-α alone [1]. MMI-0100 (1 mM) treatment also increases both EC (11%) and SMC (7%) proliferation as compared to control, this response is not as robust as that induced by treatment with 0.5 mM MMI-0100 [1]. MMI-0100 does not induce EC apoptosis at any dose [1]. Cell Viability Assay [1]