Hsp90-Cdc37-IN-3-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Hsp90-Cdc37-IN-3 Cat. No.: HY-144650 CAS No.: 2361009-68-7 分⼦式: C₃₅H₄₄ClN₃O₆ 分⼦量: 638.19 作⽤靶点: Apoptosis; HSP 作⽤通路: Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Hsp90-Cdc37-IN-3 (Compound 9) 是⼀种具有抗癌活性 (anticancer) 的新型 celastrol−imidazole 衍⽣物。 Hsp90-Cdc37-IN-3 通过共价结合抑制 Hsp90−Cdc37，诱导细胞凋亡 (apoptosis) [1]。 IC50 Target Hsp90-Cdc37 体外研究 Hsp90-Cdc37-IN-3 (Compound 9) (24 h) shows broad-spectrum antitumor potential with IC50 values of 0.54, 0.59, 0.57, and 0.57 µM against A549, HTC116, U2OS, and MDA-MB231 cells, respectively [1]. Hsp90-Cdc37-IN-3 (0-5 µM, 12 h) inhibits Hsp90−Cdc37 and influences the function of apoptosis-related proteins by covalently combining with both Hsp90 and Cdc37 [1]. Hsp90-Cdc37-IN-3 (0-0.8 µM, 48 h) induces apoptosis significantly in A549 cells [1]. Hsp90-Cdc37-IN-3 (0-0.4 µM, 24 h) arrests the cell cycle in the G0/G1 phase in a dose-dependent manner [1]. Western Blot Analysis [1] Cell Line: A549