MELK-8a-NVS-MELK8a-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE MELK-8a Cat. No.: HY-100368 CAS No.: 1922153-17-0 Synonyms: NVS-MELK8a 分⼦式: C₂₅H₃₂N₆O 分⼦量: 432.56 作⽤靶点: MELK; PDGFR 作⽤通路: PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 MELK-8a (NVS-MELK8a) 是⼀种⾼效的选择性母体胚胎亮氨酸拉链激酶 (MELK) 抑制剂，IC50 为 2 nM。MELK- 8a 还抑制 Flt3 (ITD)、Haspin、PDGFR α，IC50 分别为 0.18、0.19 和 0.42 μM。 MELK 在调节癌细胞的细胞 有丝分裂中发挥着重要作⽤ [1]。 客户使⽤本产品发表的科研⽂献 • Cell Rep. 2017 Dec 5;21(10):2829-2841. • J Biol Chem. 2020 Feb 21;295(8):2359-2374. • School of Medicine, Department of Pharmacology. 2020 Jun. See more customer validations on www.MedChemE REFERENCES [1]. B Barry Touré, et al. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J Med Chem. 2016 May 26;59(10):4711-23. McePdfHeight Caution: Product has not been fully validated for medical applications.