Etoxadrol-NSC-288020-DataSheet-生命科学试剂-MedChemExpress.pdf

Hotline: 400-820-3792 Inhibitors • Screening Libraries • Proteins www.MedChemE Etoxadrol Cat. No.: HY-107040 CAS No.: 28189-85-7 Synonyms: NSC 288020; CL-1848C 分⼦式: C₁₆H₂₃NO₂ 分⼦量: 261.36 作⽤靶点: Others 作⽤通路: Others 储存⽅式: Please store the product under the recommended conditions in the Certificate of Analysis. BIOLOGICAL ACTIVITY ⽣物活性 Etoxadrol (CL-1848C) 是⼀个有效的、具有⾼亲和性的 N-methyl-D-aspartic acid (NMDA) 拮抗剂。Etoxadrol 可⽤于⿇醉剂 (anaesthetic) 的研究 [1]。 IC50 Target NMDA [1] 体内研究 Etoxadrol (CL-1848C) (100.0 mg/kg; i.h.; once) produces marked stimulation and ataxia in mice [2]. Etoxadrol (0-20 mg/kg; i.v.; once) decreases brain monoamine concentrations after 4 h injection [3]. Animal Model: Carworth-Farm (Upjohn) male mice weighing 18 to 20 gm [2] Dosage: 100.0 mg/kg Administration: Subcutaneous injection, 30 min Result: Produced marked stimulation and ataxia. Animal Model: Male CFE rats weighing 110-175 g (average 130 g) [3] Dosage: 5, 10, and 20 mg/kg Administration: Intravenous injection, once Result: Significantly lowered brain serotonin, DA (dopamine), and NE (norepinephrine) 1/2