妇科肿瘤标志物的研究进展.pptVIP

HE4与CA125的关系？ Ctrl = healthy controls; Endo = endometriosis; EOC = endometrial ovarian cancer Huhtinen, K. et al. (2009). Br J Cancer. 100(8), 1315-1319. HE4: 子宫内膜异位症几乎不升高 HE4: 卵巢癌显著升高 CA125: 子宫内膜异位症轻微升高 CA125: 卵巢癌显著升高 更好鉴别诊断子宫内膜异位症 CA125和HE4合用更好的鉴别子宫内膜异位症 子宫内膜异位症 子宫内膜异位症 病例分享 卵巢癌 (n=129) HE4 (-) CA125 (-) HE4 (-) CA125 (+) HE4 (+) CA125 (+) HE4 (+) CA125 (-) Total 9% (n=12) 11% (n=14) 71% (n=92) 9% (n=11) CA125 (+) CA125 (+) HE4 (+) Brown et al. (2008). Differential expression of CA 125 and a novel serum tumor marker HE4 in epithelial ovarian cancer, ASCO. Moore RG et al. Gynecologic Onco