生物化学和分子生物学：beta-lactams.pptVIP

Antibacterial AgentsAntibioticsSynthetic AgentsNaturalAntibioticsSemisyntheticAntibiotics b－Lactam AntibioticsAntibiotics with b－Lactam: Penicillins, Cephalosporins, Carbapenems, Cephamycins, Oxacephems, Monobactams CharacteristicsWide spectrumStrong antibacterial activityLow toxicitySignificant curative effect Mechanism of action1. Target PBPs (penicillin binding proteins)Bind to PBP(s)→inhibit transpeptidase→inhibit crosslink of peptidoglycan strands→defect of cell walls→swelling and deformation→lysis and break down of bacteriaPBPs differ in strains: 7 types in E.coliPBP1, PBP2, and PBP3 a